The Lower Deschutes continues to be the spot for really strong evening caddis hatches. Tan #14-16 caddis mixed with smaller black micro caddis are the 2 most important emergent and dry fly opportunities you’ll encounter. Most days after 7 PM you will also get fishable hatches of Pale Evening Duns so add a #12-15 Purple Haze, Parachute Adams, Cut Wing Extended Body Dun and Parachute PED. 
PMD’s are also in the mix, although maybe not as consistent now as the PED and Caddis hatches are. 
Nymph action during the day is often excellent, and while all the usual euro nymphs and caddis pupa are thought of by you and me, I really recommend also considering leeches, sculpins, euro streamers and crayfish.