The Middle Deschutes River is a good place to go now, with good hatches of tan caddis #14-16, brown caddis #16-18, olive caddis #16, PMD’s #16 and PED’s #12-14. 
There is a ton of good euro nymphing water from Bend to Lake Billy Chinook and you can attack this water anytime with the nymphing rod. Hatches are usually best in the evening but the later morning and early afternoon hatch, especially when talking about PMD mayflies is very possible.